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ea0029p1419 | Pituitary Clinical | ICEECE2012

Immunohistochemical detection of sstr2 and 5 ligand binding domains in 110 pituitary tumors

Rossi V. , Ilardi G. , Massimo M. , Bellastella G. , Visconti D. , Staibano S. , Del Basso De Caro M. , Abbondanza C. , Cavallo L. , De Bellis A. , Cappabianca P. , Colao A. , De Rosa G. , Bellastella A. , Sinisi A.

Classical somatostatin analogues (SST-A), such as octreotide and lanreotide, bind mainly SSTR2 whilst the multiligand pasireotide binds with the highest affinity SSTR5. The selective immunodetection of ligand binding domain (LBD) of SSTR subtypes with specific monoclonal antibodies may be useful to explain the potential efficacy of different SSTA on pituitary tumours growth and/or secretory activity.Patients and Methods: We applied new monoclonal antibod...

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Immunohistochemical detection of sstr2 and 5 ligand binding domains in 110 pituitary tumors

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